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Potential of human fetal chorionic stem cells for the treatment of osteogenesis imperfecta.

Abstract:

Osteogenesis imperfecta (OI) is a genetic bone pathology with prenatal onset, characterized by brittle bones in response to abnormal collagen composition. There is presently no cure for OI. We previously showed that human first trimester fetal blood mesenchymal stem cells (MSCs) transplanted into a murine OI model (oim mice) improved the phenotype. However, the clinical use of fetal MSC is constrained by their limited number and low availability. In contrast, human fetal early chorionic stem ...

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Publisher copy:
10.1089/scd.2013.0132

Authors


Moschidou, D More by this author
Abdulrazzak, H More by this author
Kalirai, BS More by this author
Vanleene, M More by this author
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Journal:
Stem cells and development
Volume:
23
Issue:
3
Pages:
262-276
Publication date:
2014-02-05
DOI:
EISSN:
1557-8534
ISSN:
1547-3287
URN:
uuid:3293800c-2cc4-4fe5-bd05-55ae652967c2
Source identifiers:
429246
Local pid:
pubs:429246

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