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Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independent of obesity

Abstract:

We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterize their association with intermediate phenotypes, and to investigate their role in type 2 diabetes (T2D) risk among normal-weight, overweight, and obese individuals. We investigated the association of genetic scores with euglycemic-hyperinsulinemic clamp- and oral glucose tolerance test-based measures of insulin resistance and secretion and a range of metabolic measures in up to 18,565 ind...

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Publisher copy:
10.2337/db14-0319/-/DC1

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Publisher:
American Diabetes Association Inc.
Journal:
Diabetes
Volume:
63
Issue:
12
Pages:
4378-4387
Publication date:
2014-12-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
URN:
uuid:327feb83-6270-4f6e-98dc-a001c6f04ce9
Source identifiers:
492527
Local pid:
pubs:492527
Language:
English

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