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Evaluation of type 2 diabetes genetic risk variants in Chinese adults: findings from 93,000 individuals from the China Kadoorie Biobank

Abstract:

Genome-wide association studies (GWAS) have discovered many risk variants for type 2 diabetes. However, estimates of the contributions of risk variants to type 2 diabetes predisposition are often based on highly selected case-control samples, and reliable estimates of population-level effect sizes are missing, especially in non-European populations.The individual and cumulative effects of 59 established type 2 diabetes risk loci were measured in a population-based China Kadoorie Biobank (CKB)...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1007/s00125-016-3920-9

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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
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Institution:
University of Oxford
Department:
Oxford, MSD, Nuffield Department of Population Health, Clinical Trial Service Unit
Millwood, IY More by this author
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Publisher:
Springer Berlin Heidelberg Publisher's website
Journal:
Diabetologia Journal website
Volume:
59
Issue:
7
Pages:
1446-1457
Publication date:
2016-04-06
Acceptance date:
2016-02-22
DOI:
EISSN:
1432-0428
ISSN:
0012-186X
URN:
uuid:327e4575-cb35-4559-a86e-eadec728e51d
Source identifiers:
614466
Local pid:
pubs:614466

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