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Journal article

Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF.

Abstract:

Integrin alpha3beta1 is a major receptor for laminin. The expression levels of laminins-8 and -10 in the basement membrane surrounding blood vessels are known to change during tumor angiogenesis. Although some studies have suggested that certain ligands of alpha3beta1 can affect angiogenesis either positively or negatively, either a direct in vivo role for alpha3beta1 in this process or its mechanism of action in endothelial cells during angiogenesis is still unknown. Because the global genet...

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Publication status:
Published

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Publisher copy:
10.2353/ajpath.2010.100043

Authors


da Silva, RG More by this author
Robinson, SD More by this author
Reynolds, LE More by this author
Szekeres, C More by this author
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Journal:
The American journal of pathology
Volume:
177
Issue:
3
Pages:
1534-1548
Publication date:
2010-09-05
DOI:
EISSN:
1525-2191
ISSN:
0002-9440
URN:
uuid:32795d30-3b47-4905-9bb3-8afe0532b860
Source identifiers:
125068
Local pid:
pubs:125068

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