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Quantitative variation in plasma angiotensin-I converting enzyme activity shows allelic heterogeneity in the ABO blood group locus.

Abstract:

Angiotensin-I converting enzyme (ACE) occupies a pivotal role in cardiovascular homeostasis. Major loci for plasma ACE have been identified at ACE on Chromosome 17 and at ABO on Chromosome 9. We sought to characterise the genetic architecture of plasma ACE at finer resolution in two populations. We carried out a GWAS in 1810 individuals of Japanese ethnicity; this identified signals at ACE and ABO that together accounted for nearly half of the population variability of the trait. We conducted...

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Publication status:
Published

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Publisher copy:
10.1111/ahg.12034

Authors


Bayoumi, N More by this author
McKenzie, CA More by this author
Zelenika, D More by this author
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Journal:
Annals of human genetics
Volume:
77
Issue:
6
Pages:
465-471
Publication date:
2013-11-05
DOI:
EISSN:
1469-1809
ISSN:
0003-4800
URN:
uuid:3273ea2d-8880-4823-bdb7-e8c0316ca757
Source identifiers:
418558
Local pid:
pubs:418558
Language:
English
Keywords:

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