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Strontium can increase some osteoblasts without increasing hematopoietic stem cells.

Abstract:

Osteoblasts are a key component in the regulation of the hematopoietic stem cell (HSC) niche. Manipulating osteoblast numbers results in a parallel change in HSC numbers. We tested the activity of strontium (Sr), a bone anabolic agent that enhances osteoblast function and inhibits osteoclast activity, on hematopoiesis. In vitro treatment of primary murine osteoblasts with Sr increased their ability to form bone nodules, and in vivo it increased osteoblast number, bone volume, and trabecular t...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Journal:
Blood
Volume:
111
Issue:
3
Pages:
1173-1181
Publication date:
2008-02-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:3267b4fc-4792-41ea-b02e-363761c48e33
Source identifiers:
223518
Local pid:
pubs:223518

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