T cell antigen receptor (TCR) and coreceptor ligation is thought to initiate signal transduction by inducing activation of the kinase Lck. Here we showed that catalytically active Lck was present in unstimulated naive T cells and thymocytes and was readily detectable in these cells in lymphoid organs. In naive T cells up to approximately 40% of total Lck was constitutively activated, part of which was also phosphorylated on the C-terminal inhibitory site. Formation of activated Lck was indepe...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Constitutively active Lck kinase in T cells drives antigen receptor signal transduction.
Views and Downloads
If you are the owner of this record, you can report an update to it here: Report update to this record