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When signalling goes wrong: pathogenic variants in structural and signalling proteins causing cardiomyopathies

Abstract:

Cardiomyopathies are a diverse group of cardiac disorders with distinct phenotypes, depending on the proteins and pathways affected. A substantial proportion of cardiomyopathies are inherited and those will be the focus of this review article. With the wide application of high-throughput sequencing in the practice of clinical genetics, the roles of novel genes in cardiomyopathies are recognised. Here, we focus on a subgroup of cardiomyopathy genes [TTN, FHL1, CSRP3, FLNC and PLN, coding for T...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s10974-017-9487-3

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM; RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More from this funder
Funding agency for:
Gehmlich, K
Grant:
201543/B/16/Z
More from this funder
Funding agency for:
Thomson, K
Grant:
NIHR-HCS-D13-04-006
More from this funder
Funding agency for:
Jiang, H
Gehmlich, K
Grant:
201543/B/16/Z
201543/B/16/Z
More from this funder
Funding agency for:
Ehsan, M
Publisher:
Springer Verlag
Journal:
Journal of Muscle Research and Cell Motility More from this journal
Volume:
38
Issue:
3-4
Pages:
306-316
Publication date:
2017-11-08
Acceptance date:
2017-10-28
DOI:
EISSN:
1573-2657
ISSN:
0142-4319
Keywords:
Pubs id:
pubs:745095
UUID:
uuid:325245c1-e224-4496-98e8-f0ab30cdfcdb
Local pid:
pubs:745095
Source identifiers:
745095
Deposit date:
2017-11-13

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