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Distinct role of lymphocyte function-associated antigen-1 in mediating effective cytolytic activity by cytotoxic T lymphocytes.

Abstract:

Lymphocyte function-associated antigen-1 (LFA-1) interaction with intercellular adhesion molecules (ICAMs) facilitates T cell antigen receptor (TCR)-mediated killing. To dissect TCR and LFA-1 contributions, we evaluated cytolytic activity and granule release by cytotoxic T lymphocytes (CTL) as well as intracellular granule redistribution and morphology of CTL stimulated with natural TCR ligand in the presence or absence of LFA-1 engagement. Although other adhesion mechanisms, e.g., CD2-CD58 i...

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Publisher copy:
10.1073/pnas.0502467102

Authors


Anikeeva, N More by this author
Somersalo, K More by this author
Thomas, VK More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
102
Issue:
18
Pages:
6437-6442
Publication date:
2005-05-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:324de00b-39fb-4492-9b35-9ff3f8cb0fb2
Source identifiers:
482625
Local pid:
pubs:482625

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