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Journal article

Experimental limitations of extracellular vesicle-based therapies for the treatment of myocardial infarction

Abstract:

Extracellular vesicles (EVs) are particles secreted by a vast variety of cells and are often recognised to mimic the properties of their parent cell, as such those derived from developmental sources hold promise for the treatment of various diseases including myocardial infarction (MI). Here we review the experimental approaches taken for assessing the therapeutic efficacy of EVs for MI and find overt shortcomings regarding purity of isolated EVs, quantitation, dosing, EV labelling/uptake, ro...

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Publication status:
In press
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.tcm.2020.08.003

Authors


Kennedy, TL More by this author
Russell, AJ More by this author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
ORCID:
0000-0002-9862-7332
Publisher:
Elsevier Publisher's website
Journal:
Trends in cardiovascular medicine Journal website
Publication date:
2020-08-18
Acceptance date:
2020-08-14
DOI:
EISSN:
1873-2615
ISSN:
1050-1738
Pmid:
32822840
Pubs id:
1129381
Local pid:
pubs:1129381

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