Journal article
Glucose and glutamine availability regulate HepG2 transcriptional responses to low oxygen
- Abstract:
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Background: Little is known about the impact of nutrients on cellular transcriptional responses, especially in face of environmental stressors such as oxygen deprivation. Hypoxia-inducible factors (HIF) coordinate the expression of genes essential for adaptation to oxygen-deprived environments. A second family of oxygen-sensing genes known as the alpha-ketoglutarate-dependent dioxygenases are also implicated in oxygen homeostasis and epigenetic regulation. The relationship between nutritio...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Version of record, pdf, 2.3MB)
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- Publisher copy:
- 10.12688/wellcomeopenres.14839.1
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Authors
Funding
Bibliographic Details
- Publisher:
- F1000Research Publisher's website
- Journal:
- Wellcome Open Research Journal website
- Volume:
- 2018
- Issue:
- 3
- Article number:
- 126
- Publication date:
- 2018-09-26
- Acceptance date:
- 2018-09-26
- DOI:
- EISSN:
-
2398-502X
- Source identifiers:
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927142
Item Description
- Pubs id:
-
pubs:927142
- UUID:
-
uuid:323658ad-d1c0-4cd5-826b-3a53401602b2
- Local pid:
- pubs:927142
- Deposit date:
- 2018-10-12
Terms of use
- Copyright holder:
- Lai et al
- Copyright date:
- 2018
- Notes:
- © 2018 Lai AG et al. This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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