Journal article
Ets, Ap-1 and GATA factor families regulate the utrophin B promoter: potential regulatory mechanisms for endothelial-specific expression.
- Abstract:
- Duchenne muscular dystrophy is caused by dystrophin deficiency, which can be prevented in the mdx mouse model by over-expression of an autosomal homologue, utrophin. Utrophin has two characterised full-length promoters, A and B. No data are available on the transcriptional regulation of B utrophin, which has been recently localised to the endothelium. Similar to characterised endothelial promoters, Ets and Ap-1 individually trans-activate the human B core promoter. Synergistic activation by GATA-2 and c-jun to the order of 20-fold was observed.
- Publication status:
- Published
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- Publisher copy:
- 10.1016/s0014-5793(03)00175-3
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Authors
Bibliographic Details
- Journal:
- FEBS letters
- Volume:
- 538
- Issue:
- 1-3
- Pages:
- 168-172
- Publication date:
- 2003-03-01
- DOI:
- EISSN:
-
1873-3468
- ISSN:
-
0014-5793
- Source identifiers:
-
106376
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:106376
- UUID:
-
uuid:322e7d08-e187-49c2-8aca-062a77c6e4a6
- Local pid:
- pubs:106376
- Deposit date:
- 2013-11-17
Terms of use
- Copyright date:
- 2003
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