Ets, Ap-1 and GATA factor families regulate the utrophin B promoter: potential regulatory mechanisms for endothelial-specific expression.

Perkins, KJ; Davies, KE

Abstract:

Duchenne muscular dystrophy is caused by dystrophin deficiency, which can be prevented in the mdx mouse model by over-expression of an autosomal homologue, utrophin. Utrophin has two characterised full-length promoters, A and B. No data are available on the transcriptional regulation of B utrophin, which has been recently localised to the endothelium. Similar to characterised endothelial promoters, Ets and Ap-1 individually trans-activate the human B core promoter. Synergistic activation by GATA-2 and c-jun to the order of 20-fold was observed.

Publication status:

Published

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APA Style

Perkins, K. J., & Davies, K. E. (2003). Ets, Ap-1 and GATA factor families regulate the utrophin B promoter: potential regulatory mechanisms for endothelial-specific expression. FEBS Letters, 538(1-3), 168–172.

MLA Style

Perkins, K. J., and K. E. Davies. “Ets, Ap-1 and GATA Factor Families Regulate the Utrophin B Promoter: Potential Regulatory Mechanisms for Endothelial-Specific Expression.” FEBS Letters, vol. 538, no. 1-3, 2003, pp. 168–72.

Chicago Style

Perkins, KJ, and KE Davies. 2003. “Ets, Ap-1 and GATA Factor Families Regulate the Utrophin B Promoter: Potential Regulatory Mechanisms for Endothelial-Specific Expression.” FEBS Letters 538 (1-3): 168–72.
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