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Mouse models of human chromosomal translocations and approaches to cancer therapy.

Abstract:

Cancer arises because of genetic changes in somatic cells, eventually giving rise to overt malignancy. Principle among genetic changes found in tumor cells are chromosomal translocations which give rise to fusion genes or enforced oncogene expression. These mutations are tumor-specific and result in production of tumor-specific mRNAs and proteins and are attractive targets for therapy. Also, in acute leukemias, many of these molecules are transcription regulators which involve cell-type-speci...

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Publisher copy:
10.1006/bcmd.2000.0371

Authors


Rabbitts, TH More by this author
Collins, EC More by this author
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Journal:
Blood cells, molecules and diseases
Volume:
27
Issue:
1
Pages:
249-259
Publication date:
2001
DOI:
EISSN:
1096-0961
ISSN:
1079-9796
URN:
uuid:3216b69a-dd20-47b5-b419-b8e37935528f
Source identifiers:
324297
Local pid:
pubs:324297

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