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Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity.

Abstract:

Human interleukin (IL) 1 receptor-associated kinase 4 (IRAK-4) deficiency is a recently discovered primary immunodeficiency that impairs Toll/IL-1R immunity, except for the Toll-like receptor (TLR) 3- and TLR4-interferon (IFN)-alpha/beta pathways. The clinical and immunological phenotype remains largely unknown. We diagnosed up to 28 patients with IRAK-4 deficiency, tested blood TLR responses for individual leukocyte subsets, and TLR responses for multiple cytokines. The patients' peripheral ...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20070628

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Journal:
The Journal of experimental medicine
Volume:
204
Issue:
10
Pages:
2407-2422
Publication date:
2007-10-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:3212de8b-f06a-4a2b-847c-13a67c7b113a
Source identifiers:
66715
Local pid:
pubs:66715

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