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A critical role for phospholipase Cgamma2 in alphaIIbbeta3-mediated platelet spreading.

Abstract:

The interaction of fibrinogen with the integrin alphaIIbbeta3 plays a crucial role in platelet adhesion and platelet activation leading to the generation of intracellular signals that nucleate the reorganization of the cytoskeleton. Presently, we have only a limited understanding of the signaling cascades and effector proteins through which changes in the cytoskeletal architecture are mediated. The present study identifies phospholipase Cgamma2 (PLCgamma2) as an important target of the Src-de...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m305077200

Authors


Wonerow, P More by this author
Pearce, AC More by this author
Watson, SP More by this author
Journal:
The Journal of biological chemistry
Volume:
278
Issue:
39
Pages:
37520-37529
Publication date:
2003-09-05
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
URN:
uuid:32094297-bff7-418a-b5cf-d04d9c1d9e50
Source identifiers:
19592
Local pid:
pubs:19592

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