Conference icon

Conference

Behavioural evaluation of cholinergic drugs.

Abstract:

Alzheimer's disease involves progressive degeneration of the cortex and the limbic system. Loss of afferent forebrain neurochemical modulatory systems is also seen, most significantly of the basal forebrain cholinergic system. Drug discovery programmes have pursued enhancement of forebrain muscarinic function as a therapeutic target. The most promising muscarinic agonists described achieve functional selectivity as agonists as the M1/M3 receptors in the CNS and M2 antagonists. These compounds...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Volume:
60
Issue:
13-14
Pages:
1145-1152
Publication date:
1997-01-01
DOI:
EISSN:
1879-0631
ISSN:
0024-3205
URN:
uuid:31fc71ee-ad5a-408c-992b-ae9704793c65
Source identifiers:
24030
Local pid:
pubs:24030

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP