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Defining the immunogenetic susceptibility to primary biliary cirrhosis.

Abstract:

Primary biliary cirrhosis is a chronic cholestatic disease, thought to be immune-mediated with genetic susceptibility encoded in the major histocompatibility complex. In northern Europeans, the best established associations are with HLA-DR8 and the complement allele, C4B2. These associations could be due to a single susceptibility locus on an extended haplotype linking HLA-DR8 and C4B2 or to both HLA-DR8 and C4B2 independently conferring disease susceptibility. C4B2 genotyping was performed o...

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Publication status:
Published

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Authors


Gregory, WL More by this author
Fleming, KA More by this author
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Journal:
Hepatology (Baltimore, Md.)
Volume:
20
Issue:
5
Pages:
1213-1219
Publication date:
1994-11-05
DOI:
EISSN:
1527-3350
ISSN:
0270-9139
URN:
uuid:31f6d3e2-9269-4cf2-a2aa-69703e523b9c
Source identifiers:
171711
Local pid:
pubs:171711

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