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Prior deafferentation confers long term protection to CA1 against transient forebrain ischemia and sustains GluR2 expression.

Abstract:

Hippocampal CA1 pyramidal neurons undergo delayed neurodegeneration after transient forebrain ischemia, and the phenomenon is dependent upon hyperactivation of l-alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) subtype of glutamate receptors, resulting in aberrant intracellular calcium influx. The GluR2 subunit of AMPA receptors is critical in limiting the influx of calcium. The CA1 pyramidal neurons are very sensitive to ischemic damage and attempts to achieve neuroprotection, med...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, Stroke and Geratology
Role:
Author
Journal:
Brain research
Volume:
1075
Issue:
1
Pages:
201-212
Publication date:
2006-02-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:31ed97bf-0aa0-4afa-b6c9-3464928befc0
Source identifiers:
79111
Local pid:
pubs:79111

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