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Biphasic decay of cell-associated HIV-1 DNA in HIV-1-infected children on antiretroviral therapy.

Abstract:
Cell-associated HIV-1 DNA was quantified in 33 HIV-1-infected children followed for 96 weeks after the initiation of antiretroviral therapy. HIV-1 DNA decay was biphasic, being 10-fold more rapid during the first 4 weeks, and was inversely associated with the baseline plasma HIV-1-RNA level, but unrelated to HIV-1-RNA suppression. HIV-1 DNA decay per absolute CD4 cell number was lower than per 106 CD4 cells, suggesting an ongoing infection of newly produced CD4 cells, despite HIV-1 suppression in plasma.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Experimental Medicine Division,
Role:
Author
Journal:
AIDS (London, England)
Volume:
16
Issue:
14
Pages:
1961-1963
Publication date:
2002-09-05
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
URN:
uuid:31e7a74a-9896-412b-85d6-37bc5ce25769
Source identifiers:
422944
Local pid:
pubs:422944

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