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Sample Size Calculations for Designing Clinical Proteomic Profiling Studies Using Mass Spectrometry

Abstract:

In cancer clinical proteomics, MALDI and SELDI profiling are used to search for biomarkers of potentially curable early-stage disease. A given number of samples must be analysed in order to detect clinically relevant differences between cancers and controls, with adequate statistical power. From clinical proteomic profiling studies, expression data for each peak (protein or peptide) from two or more clinically defined groups of subjects are typically available. Typically, both exposure and co...

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Publication status:
Published

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Publisher copy:
10.1515/1544-6115.1686

Authors


Nyangoma, SO More by this author
Collins, SI More by this author
Altman, DG More by this author
Johnson, P More by this author
Billingham, LJ More by this author
Journal:
STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY
Volume:
11
Issue:
3
Publication date:
2012
DOI:
EISSN:
1544-6115
ISSN:
2194-6302
URN:
uuid:31d25dd1-024d-4374-ba9f-0122863d1754
Source identifiers:
317869
Local pid:
pubs:317869

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