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Colorectal cancer liver metastases organoids retain characteristics of original tumor and acquire chemotherapy resistance

Abstract:

Background: Colorectal cancer (CRC) liver metastasis is highly unfavorable for patient outcome and is a leading cause of cancer-related death. Pre-clinical research of CRC liver metastasis predominately utilizes CRC cell lines grown in tissue culture. Here, we demonstrate that CRC liver metastases organoids...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.scr.2018.01.016

Authors


More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Oncology
Subgroup:
CRUK/MRC Ox Inst Radiation Oncology
Publisher:
Elsevier Publisher's website
Journal:
Stem Cell Research Journal website
Volume:
27
Pages:
109-120
Publication date:
2018-01-28
Acceptance date:
2018-01-12
DOI:
EISSN:
1876-7753
ISSN:
1873-5061
Pubs id:
pubs:823347
URN:
uri:31c79674-c29a-40f0-8319-7103127c1d1c
UUID:
uuid:31c79674-c29a-40f0-8319-7103127c1d1c
Local pid:
pubs:823347

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