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Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats.

Abstract:

The Dahl salt-sensitive rat is one of the principal animal models of hereditary hypertension. Genome-wide searches were undertaken to detect quantitative trait loci (QTLs) that influence blood pressure, cardiac mass, and body weight in four F2 populations derived from Dahl salt-sensitive rats and different inbred normotensive control strains of rat. We detected three QTLs associated with one or more of the phenotypes, using a stringent statistical criterion for linkage (p < 0.00003). These...

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Publication status:
Published

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Publisher copy:
10.1007/s003359900983

Authors


Bihoreau, MT More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Lathrop, GM More by this author
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Journal:
Mammalian genome : official journal of the International Mammalian Genome Society
Volume:
10
Issue:
3
Pages:
259-265
Publication date:
1999-03-05
DOI:
EISSN:
1432-1777
ISSN:
0938-8990
URN:
uuid:31b9afb5-0675-433e-8f2f-237de5bec4b3
Source identifiers:
13417
Local pid:
pubs:13417

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