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Mouse arylamine N-acetyltransferase 2 (Nat2) expression during embryogenesis: a potential marker for the developing neuroendocrine system.

Abstract:

Arylamine N-acetyltransferase (NAT) genes in humans and in rodents encode polymorphic drug metabolizing enzymes. Human NAT1 (and the murine equivalent mouse Nat2) is found early in embryonic development and is likely to have an endogenous role. We report the detailed expression of the murine gene (Nat2) and encoded protein in mouse embryos, using a transgenic mouse model bearing a lacZ transgene inserted into the coding region of mouse Nat2. In mouse embryos, the transgene was expressed in se...

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Publication status:
Published

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Publisher copy:
10.1080/13547500701673529

Authors


Wakefield, L More by this author
Cornish, V More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry, BHF Centre of Research Excellence
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Journal:
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Volume:
13
Issue:
1
Pages:
106-118
Publication date:
2008-02-05
DOI:
EISSN:
1366-5804
ISSN:
1354-750X
URN:
uuid:31b800d8-a898-4b4b-bf33-e6d44baa7b09
Source identifiers:
260502
Local pid:
pubs:260502

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