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The hidden truth about gene expression in Tregs: is it what you don't see that counts?

Abstract:

A population of IL-10 secreting regulatory T cells (PI-Tregs) can be induced in a mouse TCR transgenic model of experimental autoimmune encephalomyelitis (EAE) by intranasal administration of the N-terminal peptide of myelin basic protein. A paper in this issue of the European Journal of Immunology identifies patterns of gene expression that distinguish PI-Treg from naïve T cells after activation in vivo. PI-Tregs are anergic and the expression of egr2 may be involved in regulation of the cel...

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Publication status:
Published

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Publisher copy:
10.1002/eji.200636171

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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
European journal of immunology
Volume:
36
Issue:
6
Pages:
1360-1363
Publication date:
2006-06-05
DOI:
EISSN:
1521-4141
ISSN:
0014-2980
URN:
uuid:31b2029f-7c77-42e9-852d-bee0dee25262
Source identifiers:
16850
Local pid:
pubs:16850

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