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Blockade of CCK-B receptors by L-365,260 induces analgesia in the squirrel monkey.

Abstract:
The potential antinociceptive effects of the selective cholecystokinin-B (CCK-B) antagonist L-365,260 were examined in the squirrel monkey tail withdrawal test. Pain threshold was measured in 6 male monkeys by recording the latency to remove the tail from a warm (55 degrees C) water bath. L-365,260 at doses of 100 ng/kg to 100 micrograms/kg significantly elevated tail withdrawal latencies throughout a 2 h test period. These data provide the first evidence that blockade of CCK-B receptors induces analgesia in primates.
Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Role:
Author
Journal:
Brain research
Volume:
534
Issue:
1-2
Pages:
287-290
Publication date:
1990-11-05
DOI:
EISSN:
1872-6240
ISSN:
0006-8993
URN:
uuid:31aea7d2-1a06-4047-90f7-51da8def3703
Source identifiers:
29860
Local pid:
pubs:29860

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