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Virulence in rodent malaria: host genotype by parasite genotype interactions.

Abstract:

In an effort to understand what limits the virulence of malaria parasites, we infected inbred mice of three genotypes (C57Bl/6J, CBA/Ca and DBA/2) with one of two parasite lines of the rodent malaria Plasmodium chabaudi. One of these parasite lines had been serially passaged through C57Bl/6J mice and had evolved higher asexual growth rate, virulence and transmission in the process. The other parasite line was the unadapted ancestral line which had low virulence. In all three host genotypes, t...

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Role:
Author
Journal:
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
Volume:
1
Issue:
4
Pages:
287-296
Publication date:
2002-07-05
DOI:
EISSN:
1567-7257
ISSN:
1567-1348
URN:
uuid:31a94921-9f0d-476b-b704-2fe39dc5b79e
Source identifiers:
90475
Local pid:
pubs:90475

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