Nitric oxide-soluble guanylyl cyclase signaling regulates corticostriatal transmission and short-term synaptic plasticity of striatal projection neurons recorded in vivo.

Journal article

Striatal medium-sized spiny neurons (MSNs) contain the highest levels of soluble guanylyl cyclase (sGC) in the brain. Striatal sGC signaling is activated by nitric oxide (NO) and other neuromodulators. MSNs also express cGMP-dependent protein kinase and other components of the cGMP signaling system which are critically involved in integrating corticostriatal transmission and regulating synaptic plasticity in striatal networks. However, the influence of tonic and phasic activation of this sign...

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Authors: Sammut, S; Threlfell, S; West, A

• Publication status: Published
• Journal: Neuropharmacology
• Volume: 58
• Issue: 3
• Pages: 624-631
• Publication date: 2010-03-01
• DOI: 10.1016/j.neuropharm.2009.11.011
• EISSN: 1873-7064
• ISSN: 0028-3908
• Language: English
• Keywords: Animals; Receptors, Cytoplasmic and Nuclear; Rats, Sprague-Dawley; Guanylate Cyclase; Biophysics; Analysis of Variance; Action Potentials; Time Factors; Quinoxalines; Enzyme Inhibitors; Drug Interactions; Neuronal Plasticity; Frontal Lobe; Male; Signal Transduction; Indazoles; Nitric Oxide; Rats; Corpus Striatum; Synaptic Transmission; Neural Inhibition; Neurons; Neural Pathways; Oxadiazoles; Electric Stimulation