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Thesis

Phenotypic modelling of the polyfunctional T cell response

Abstract:

T cells are important mediators of adaptive immunity and promising agents in immunotherapies. When T cell receptors (TCRs) on the surface of CD8+ T cells detect pathogenic peptides presented by major histocompatibility complexes class I (pMHC) on antigen-presenting cells (APCs), a complicated intracellular signalling process is initiated that results, among other functional responses, in the secretion of cytokines to fight the pathogenic threat. An overwhelming number of molecular componen...

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Division:
MSD
Department:
Pathology Dunn School
Department:
Sir William Dunn School of Pathology and Systems Biology DTC, University of Oxford
Role:
Author

Contributors

Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Examiner
Department:
School of Veterinary Sciences, University of Bristol
Role:
Examiner
Engineering and Physical Sciences Research Council More from this funder
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:31a57248-5825-4534-89ef-b63ec7e085cc
Deposit date:
2019-01-24

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