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Ultrasensitive fluorescence-based methods for nucleic acid detection: towards amplification-free genetic analysis.

Abstract:

Real time PCR is the mainstay of current nucleic acid assays, underpinning applications in forensic science, point-of-care diagnostics and detection of bioterrorism agents. Despite its broad utility, the search for new tests continues, inspired by second and third generation DNA sequencing technologies and fuelled by progress in single molecule fluorescence spectroscopy, nanotechnology and microfabrication. These new methods promise the direct detection of nucleic acids without the need for e...

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Publication status:
Published

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Publisher copy:
10.1039/c0cc04215c

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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Role:
Author
Journal:
Chemical communications (Cambridge, England)
Volume:
47
Issue:
13
Pages:
3717-3735
Publication date:
2011-04-05
DOI:
EISSN:
1364-548X
ISSN:
1359-7345
URN:
uuid:31a0c1d4-4acb-4502-b4d5-421faf80bc9e
Source identifiers:
399992
Local pid:
pubs:399992

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