Crystal structure of an active form of human MMP-1.

Journal article

The extracellular matrix is a dynamic environment that constantly undergoes remodelling and degradation during vital physiological processes such as angiogenesis, wound healing, and development. Unbalanced extracellular matrix breakdown is associated with many diseases such as arthritis, cancer and fibrosis. Interstitial collagen is degraded by matrix metalloproteinases with collagenolytic activity by MMP-1, MMP-8 and MMP-13, collectively known as the collagenases. Matrix metalloproteinase 1 ...

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Authors: Iyer, S; Visse, R; Nagase, H; Acharya, K

• Publication status: Published
• Journal: Journal of molecular biology
• Volume: 362
• Issue: 1
• Pages: 78-88
• Publication date: 2006-09-01
• DOI: 10.1016/j.jmb.2006.06.079
• EISSN: 1089-8638
• ISSN: 0022-2836
• Language: English
• Keywords: Hemopexin; Models, Molecular; Hydrogen Bonding; Catalytic Domain; Humans; Crystallography, X-Ray; Enzyme Precursors; Molecular Sequence Data; Animals; Matrix Metalloproteinase 1; Collagenases; Swine; Protein Structure, Tertiary