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Crystal structure of an active form of human MMP-1.

Abstract:

The extracellular matrix is a dynamic environment that constantly undergoes remodelling and degradation during vital physiological processes such as angiogenesis, wound healing, and development. Unbalanced extracellular matrix breakdown is associated with many diseases such as arthritis, cancer and fibrosis. Interstitial collagen is degraded by matrix metalloproteinases with collagenolytic activity by MMP-1, MMP-8 and MMP-13, collectively known as the collagenases. Matrix metalloproteinase 1 ...

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Publication status:
Published

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Publisher copy:
10.1016/j.jmb.2006.06.079

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Journal of molecular biology
Volume:
362
Issue:
1
Pages:
78-88
Publication date:
2006-09-05
DOI:
EISSN:
1089-8638
ISSN:
0022-2836
URN:
uuid:319c49f6-462e-470c-bd46-e3fcbf88b08b
Source identifiers:
226885
Local pid:
pubs:226885

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