Silencing of Dok-7 in adult rat muscle increases susceptibility to passive transfer myasthenia gravis

Journal article

Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies that target proteins at the neuromuscular junction, primarily the acetylcholine receptor (AChR) and the muscle-specific kinase. Because downstream of kinase 7 (Dok-7) is essential for the full activation of muscle-specific kinase and consequently for dense clustering of AChRs, we hypothesized that reduced levels of Dok-7 increase the susceptibility to passive transfer MG. To test this hypothesis, Dok-7 expression was r...

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Authors: Gomez, A; Stevens, J; Mané-Damas, M; Molenaar, P; Duimel, H

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: American Journal of Pathology
• Volume: 186
• Issue: 10
• Pages: 2559-2568
• Publication date: 2016-09-24
• Acceptance date: 2016-05-19
• DOI: 10.1016/j.ajpath.2016.05.025
• EISSN: 1525-2191
• ISSN: 0002-9440
• Pmid: 27658713
• Language: English
• Keywords: Neuromuscular Junction; Receptors, Cholinergic; Synaptic Transmission; Female; HEK293 Cells; Muscle Proteins; Down-Regulation; Disease Susceptibility; Gene Silencing; Disease Models, Animal; Genes, Reporter; Receptor Protein-Tyrosine Kinases; Myasthenia Gravis, Autoimmune, Experimental; Rats, Inbred Lew; Humans; Autoantibodies; Muscle, Skeletal; Rats; Journal Article; Animals