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Multimers of the fibroblast growth factor (FGF)-FGF receptor-saccharide complex are formed on long oligomers of heparin.

Abstract:

The minimal signalling unit for tyrosine kinase receptors is two protomers dimerized by one or more ligands. However, it is clear that maximal signalling requires the formation of larger complexes of many receptors at discrete foci on the cell surface. The biological interactions that lead to this are likely to be diverse and have system specific components. In the present study, we demonstrate that, in the FGF (fibroblast growth factor)-FGFR (FGF receptor) system, multimers of the minimal co...

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Publication status:
Published

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Publisher copy:
10.1042/bj20050985

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Journal:
The Biochemical journal
Volume:
393
Issue:
Pt 3
Pages:
741-748
Publication date:
2006-02-05
DOI:
EISSN:
1470-8728
ISSN:
0264-6021
URN:
uuid:31991b4d-9cd1-4967-b7c4-db5adca7ebde
Source identifiers:
59279
Local pid:
pubs:59279

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