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Dynamics of neuronal assemblies are modulated by anaesthetics but not analgesics.

Abstract:

BACKGROUND AND OBJECTIVE: Analgesics and anaesthetics have diverse synaptic actions that nonetheless have a common net inhibitory action on neuronal discharge. It is puzzling, therefore, that these two classes of compounds have fundamentally different affects, one blocking pain and the other consciousness. Indeed, beyond the isolated synapse, little is known of the larger scale mechanisms that mediate actual function, for example, transient neuronal assemblies. It was hypothesized that the t...

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Publication status:
Published

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Publisher copy:
10.1017/s0265021506002390

Authors


Collins, TF More by this author
Dommett, EJ More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
Journal:
European journal of anaesthesiology
Volume:
24
Issue:
7
Pages:
609-614
Publication date:
2007-07-05
DOI:
EISSN:
1365-2346
ISSN:
0265-0215
URN:
uuid:31945089-ec2d-4e17-8503-be70a6e0a950
Source identifiers:
185128
Local pid:
pubs:185128

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