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A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.

Abstract:

The jumonji (JMJ) family of histone demethylases are Fe2+- and α-ketoglutarate-dependent oxygenases that are essential components of regulatory transcriptional chromatin complexes. These enzymes demethylate lysine residues in histones in a methylation-state and sequence-specific context. Considerable effort has been devoted to gaining a mechanistic understanding of the roles of histone lysine demethylases in eukaryotic transcription, genome integrity and epigenetic inheritance, as well as in ...

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Publisher copy:
10.1038/nature11262

Authors


Kruidenier, L More by this author
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Journal:
Nature
Volume:
488
Issue:
7411
Pages:
404-408
Publication date:
2012-08-16
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
URN:
uuid:3193b335-b61d-4615-8cd8-bea4214a3cc8
Source identifiers:
343991
Local pid:
pubs:343991

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