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CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions.

Abstract:

CD40-CD40 ligand (CD40L) interaction is required for the generation of antibody responses to T-dependent antigens as well as for the development of germinal centers and memory B cells. The role of the CD40-CD40L interaction in the induction of antigen-specific. Th cells and in mediating Th cell effector functions other than cognate help for B cells is less well understood. Using CD40- and CD40L-deficient mice together with lymphocytic choriomeningitis virus and vesicular stomatitis virus as v...

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Publication status:
Published

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Publisher copy:
10.1084/jem.183.5.2209

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Journal:
The Journal of experimental medicine
Volume:
183
Issue:
5
Pages:
2209-2218
Publication date:
1996-05-05
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
URN:
uuid:318f4f55-a965-4ab9-aa6a-acd3ddaaf99f
Source identifiers:
469175
Local pid:
pubs:469175

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