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Tau phosphorylation in human brain: relationship to behavioral disturbance in dementia.

Abstract:

Agitation and aggressive behavior are common symptoms of Alzheimer's disease (AD), and tangle density in frontal cortex is a possible regional substrate of these behaviors. To investigate this further, 16 AD patients, 8 patients with non-AD dementia, and 13 age-matched control subjects for frontal cortex and, respectively, 21, 7, and 6 patients for parietal cortex were analyzed for tau and phospho-tau by enzyme-linked immunosorbent assay (ELISA). Agitation/aggression was determined by the Pre...

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Publication status:
Published

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Authors


Guadagna, S More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Williams, RJ More by this author
Francis, PT More by this author
Journal:
Neurobiology of aging
Volume:
33
Issue:
12
Pages:
2798-2806
Publication date:
2012-12-05
DOI:
EISSN:
1558-1497
ISSN:
0197-4580
URN:
uuid:318b0bda-23ba-4906-9a2d-a671d40af227
Source identifiers:
316266
Local pid:
pubs:316266

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