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Journal article

Distinct recognition modes of FXXLF and LXXLL motifs by the androgen receptor.

Abstract:

Among nuclear receptors, the androgen receptor (AR) is unique in that its ligand-binding domain (LBD) interacts with the FXXLF motif in the N-terminal domain, resembling coactivator LXXLL motifs. We compared AR- and estrogen receptor alpha-LBD interactions of the wild-type AR FXXLF motif and coactivator transcriptional intermediary factor 2 LXXLL motifs and variants of these motifs. Random mutagenesis revealed a key role for the F residues in FXXLF motifs in high-affinity and selective AR LBD...

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Publication status:
Published

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Publisher copy:
10.1210/me.2003-0375

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Journal:
Molecular endocrinology (Baltimore, Md.)
Volume:
18
Issue:
9
Pages:
2132-2150
Publication date:
2004-09-05
DOI:
EISSN:
1944-9917
ISSN:
0888-8809
URN:
uuid:3163a513-993e-4c42-ac74-eb6397e377e0
Source identifiers:
317568
Local pid:
pubs:317568

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