- Abstract:
-
Compared to other specialties, nephrology has reported relatively few clinical trials, and most of these are too small to detect moderate treatment effects. Consequently, interventions that are commonly used by nephrologists have not been adequately tested and some may be ineffective or harmful. More randomized trials are urgently needed to address important clinical questions in patients with kidney disease. The use of robust surrogate markers may accelerate early-phase drug development. How...
Expand abstract - Publication status:
- Published
- Peer review status:
- Peer reviewed
- Files:
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(pdf)
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- Publisher copy:
- 10.1038/s41581-019-0212-x
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- Publisher:
- Nature Research Publisher's website
- Journal:
- Nature Reviews Nephrology Journal website
- Volume:
- 16
- Pages:
- 173–185
- Publication date:
- 2019-10-31
- Acceptance date:
- 2019-09-18
- DOI:
- EISSN:
-
1759-507X
- ISSN:
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1759-5061
- Pubs id:
-
pubs:1069866
- UUID:
-
uuid:31625f85-9706-470b-90b3-edc888e140ce
- Source identifiers:
-
1069866
- Local pid:
- pubs:1069866
- Language:
- English
- Keywords:
- Copyright holder:
- Springer Nature
- Rights statement:
- Copyright © 2019, Springer Nature
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://doi.org/10.1038/s41581-019-0212-x
Journal article
Kidney disease trials for the 21st century: innovations in design and conduct
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