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Durable response of spinal chordoma to combined inhibition of IGF-1R and EGFR

Abstract:

Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases including epidermal growth factor receptor (EGFR) and type 1 insulin-like growth factor receptor (IGF-1R) in chordoma biology. We report an adult female patient who presented in 2003 with spinal chordoma, treated with sur...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fonc.2016.00098

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MPLS
Department:
Engineering Science
Sub department:
Institute of Biomedical Engineering
Role:
Author
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Breast Cancer Now More from this funder
Prostate Cancer UK More from this funder
Rosetrees Trust More from this funder
UCARE-Oxford More from this funder
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Oncology Journal website
Publication date:
2016-05-02
Acceptance date:
2016-04-07
DOI:
ISSN:
2234-943X
Source identifiers:
615004
Keywords:
Pubs id:
pubs:615004
UUID:
uuid:315fcec6-b034-41e1-9b93-644658ca03ed
Local pid:
pubs:615004
Deposit date:
2016-04-13

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