Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases including epidermal growth factor receptor (EGFR) and type 1 insulin-like growth factor receptor (IGF-1R) in chordoma biology. We report an adult female patient who presented in 2003 with spinal chordoma, treated with sur...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Publisher's version
- Copyright holder:
- Aleksic et al.
- Copyright date:
- Copyright © 2016 the authors. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Durable response of spinal chordoma to combined inhibition of IGF-1R and EGFR
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