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Durable response of spinal chordoma to combined inhibition of IGF-1R and EGFR

Abstract:

Chordomas are rare primary malignant bone tumors arising from embryonal notochord remnants of the axial skeleton. Chordomas commonly recur following surgery and radiotherapy, and there is no effective systemic therapy. Previous studies implicated receptor tyrosine kinases including epidermal growth factor receptor (EGFR) and type 1 insulin-like growth factor receptor (IGF-1R) in chordoma biology. We report an adult female patient who presented in 2003 with spinal chordoma, treated with sur...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.3389/fonc.2016.00098

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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oncology, Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Oxford NIHR Biomedical Research Centre
Role:
Author
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Breast Cancer Now More from this funder
Prostate Cancer UK More from this funder
Rosetrees Trust More from this funder
UCARE-Oxford More from this funder
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Oncology Journal website
Publication date:
2016-05-02
DOI:
ISSN:
2234-943X
URN:
uuid:315fcec6-b034-41e1-9b93-644658ca03ed
Source identifiers:
615004
Local pid:
pubs:615004

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