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Journal article

FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development

Abstract:

FBXW7 is the substrate recognition component of a SCF-type E3 ubiquitin ligase. It has multiple targets such as Notch1, c-Jun, and cyclin E that function in critical developmental and signalling pathways. Mutations in FBXW7 are often found in many types of cancer. In most cases, these mutations do not inactivate the protein, but are mono-allelic missense changes at specific arginine resides involved in substrate binding. We have hypothesized that FBXW7 mutations are selected in cancers for re...

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Publisher copy:
10.1002/path.2874

Authors


Spencer-Dene, B More by this author
Tateossian, H More by this author
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Journal:
Journal of Pathology
Volume:
224
Issue:
2
Pages:
180-189
Publication date:
2011-06-05
DOI:
EISSN:
1096-9896
ISSN:
0022-3417
URN:
uuid:315e6cd9-2d73-4962-b4d5-325ac9c5fd62
Source identifiers:
149856
Local pid:
pubs:149856
Language:
English
Keywords:

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