- Abstract:
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In recent years, Genome-wide association studies (GWAS) have identified several susceptibility-modifying genetic variants to complex diseases such as multiple sclerosis (MS). An association for one such single nucleotide polymorphism (SNP) in the gene encoding the principle receptor for the cytokine TNF (TNFR1), TNFRSF1A, has been replicated several times since its initial identification by De Jager et al., 2009. This study demonstrates that the MS risk-associated G allele of this SNP, rs1...
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- Publication date:
- 2012
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Copyright holder:
- Adam Gregory
- Copyright date:
- 2012
Thesis
Functional characterisation of a multiple sclerosis-associated genetic variant
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