Multipotent basal stem cells, maintained in localized proximal niches, support directed long-ranging epithelial flows in human prostates
Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the identity and lineage potential of stem cells within human tissues. By combining quantitative clonal mapping with 3D reconstruction of adult human prostates, we show that multipotent basal stem cells, confined to discrete niches in juxta-urethral ducts, generate bipotent basal progenitors in directed epithelial migration streams. Basal progenitors are then dispersed throughout the entire glandular network, divid...Expand abstract
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- Moad et al
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Copyright © 2017 The Authors.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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