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Multipotent basal stem cells, maintained in localized proximal niches, support directed long-ranging epithelial flows in human prostates

Abstract:

Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the identity and lineage potential of stem cells within human tissues. By combining quantitative clonal mapping with 3D reconstruction of adult human prostates, we show that multipotent basal stem cells, confined to discrete niches in juxta-urethral ducts, generate bipotent basal progenitors in directed epithelial migration streams. Basal progenitors are then dispersed throughout the entire glandular network, divid...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1016/j.celrep.2017.07.061

Authors


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Royal College of Surgeons of England More from this funder
Trinity College, Cambridge More from this funder
Bettencourt-Schueller Young Researcher Prize More from this funder
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Publisher:
Cell Press Publisher's website
Journal:
Cell Reports Journal website
Volume:
20
Issue:
7
Pages:
1609-1622
Publication date:
2017-08-15
Acceptance date:
2017-07-21
DOI:
ISSN:
2211-1247
Pubs id:
pubs:724099
URN:
uri:315d41a5-229c-4785-b09e-f68aa3310dd9
UUID:
uuid:315d41a5-229c-4785-b09e-f68aa3310dd9
Local pid:
pubs:724099
Paper number:
7

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