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MicroRNA expression in abdominal and gluteal adipose tissue is associated with mRNA expression levels and partly genetically driven.

Abstract:

To understand how miRNAs contribute to the molecular phenotype of adipose tissues and related traits, we performed global miRNA expression profiling in subcutaneous abdominal and gluteal adipose tissue of 70 human subjects and characterised which miRNAs were differentially expressed between these tissues. We found that 12% of the miRNAs were significantly differentially expressed between abdominal and gluteal adipose tissue (FDR adjusted p<0.05) in the primary study, of which 59 replicated...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0027338

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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics
Role:
Author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Statistics, Clinical Medicine
Role:
Author
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Institution:
University of Oxford
Role:
Author
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Funding agency for:
Rantalainen, M
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Funding agency for:
Zondervan, KT
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Funding agency for:
Lindgren, CM
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Wellcome Trust More from this funder
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Publisher:
Public Library of Science Publisher's website
Journal:
PloS one Journal website
Volume:
6
Issue:
11
Pages:
Article: e27338
Publication date:
2011-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:3155e83c-5104-4662-90e9-80dbeb5df7c7
Source identifiers:
206035
Local pid:
pubs:206035

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