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To die or not to die: how does p53 decide?

Abstract:

p53 is frequently mutated in cancer and as a result is one of the most intensely studied tumour suppressors. Analysis of the primitive forms of p53 found in Caenorhabditis elegans and Drosophila, alongside studies using transgenic mouse models, indicate that the induction of apoptosis is both the most conserved function of p53 and vital for tumour suppression. p53-mediated apoptosis occurs through a combination of mechanisms which include pathways that are both dependent and independent of al...

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Publication status:
Published

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Publisher copy:
10.1038/sj.onc.1207516

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Ludwig Institute
Role:
Author
Journal:
Oncogene
Volume:
23
Issue:
16
Pages:
2809-2818
Publication date:
2004-04-05
DOI:
EISSN:
1476-5594
ISSN:
0950-9232
URN:
uuid:31528ded-e7eb-423c-a01a-fdc396e33aff
Source identifiers:
83964
Local pid:
pubs:83964

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