Journal article icon

Journal article

Toll-like receptor 2 impairs host defense in gram-negative sepsis caused by Burkholderia pseudomallei (Melioidosis).

Abstract:

BACKGROUND: Toll-like receptors (TLRs) are essential in host defense against pathogens by virtue of their capacity to detect microbes and initiate the immune response. TLR2 is seen as the most important receptor for gram-positive bacteria, while TLR4 is regarded as the gram-negative TLR. Melioidosis is a severe infection caused by the gram-negative bacterium, Burkholderia pseudomallei, that is endemic in Southeast Asia. We aimed to characterize the expression and function of TLRs in septic m...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

Actions


Access Document


Files:
Publisher copy:
10.1371/journal.pmed.0040248

Authors


Wiersinga, WJ More by this author
Wieland, CW More by this author
Dessing, MC More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Thailand/Laos MOP
Expand authors...
Netherlands Organisation for Scientific Research More from this funder
Wellcome Trust More from this funder
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS medicine Journal website
Volume:
4
Issue:
7
Pages:
Article: e248
Publication date:
2007-07-05
DOI:
EISSN:
1549-1676
ISSN:
1549-1277
URN:
uuid:313ac86a-3d4a-4d5f-8624-4300cf19bb78
Source identifiers:
4926
Local pid:
pubs:4926

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP