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Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a

Abstract:

Psoriasis is a chronic inflammatory skin disease associated with a T helper 17 response. Yet, it has proved challenging to identify relevant peptide-based T cell antigens. Antigen-presenting Langerhans cells show a differential migration phenotype in psoriatic lesions and express constitutively high levels of CD1a, which presents lipid antigens to T cells. In addition, phospholipase A2 (PLA2) is highly expressed in psoriatic lesions and is known to generate neolipid skin antigens for recognit...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher version

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Publisher copy:
10.1084/jem.20160258

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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
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Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Role:
Author
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Medical Research Council More from this funder
National Institute for Health Research More from this funder
British Association of Dermatologists More from this funder
British Skin Foundation More from this funder
Misses Barrie Charitable Trust More from this funder
Publisher:
Rockefeller University Press Publisher's website
Journal:
Journal of Experimental Medicine Journal website
Volume:
213
Issue:
11
Pages:
2399-2412
Publication date:
2016-10-26
Acceptance date:
2016-09-16
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Pubs id:
pubs:644376
URN:
uri:312e946a-9c93-4443-b04a-11fde38771c9
UUID:
uuid:312e946a-9c93-4443-b04a-11fde38771c9
Local pid:
pubs:644376

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