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Effect of the EGFR density of breast cancer cells on nuclear importation, in vitro cytotoxicity, and tumor and normal-tissue uptake of [111In]DTPA-hEGF.

Abstract:

INTRODUCTION: Our objective was to evaluate the effect of epidermal growth factor receptor(s) (EGFR) density on the importation and nuclear localization of 111In-labeled diethylenetriaminepentaacetic acid human epidermal growth factor ([111In]DTPA-hEGF) in breast cancer (BC) cells in vitro and in tumor xenografts and normal tissues in vivo in athymic mice, as well as on its cytotoxicity and tumor and normal-tissue distribution. METHODS: The internalization and nuclear importation of [111In]DT...

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Publication status:
Published

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Authors


Scollard, D More by this author
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Journal:
Nuclear medicine and biology
Volume:
34
Issue:
8
Pages:
887-896
Publication date:
2007-11-05
DOI:
EISSN:
1872-9614
ISSN:
0969-8051
URN:
uuid:312459e8-6be6-40b6-9d89-d87cc9eebfc7
Source identifiers:
308116
Local pid:
pubs:308116

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