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Upregulation of lipocalin-2 in human papillomavirus-positive keratinocytes and cutaneous squamous cell carcinomas.

Abstract:

It has been demonstrated previously that E7 oncogene expression of human papillomavirus (HPV) type 8 in keratinocytes induces cell invasion and accelerated differentiation. Looking for cellular genes deregulated by HPV-8 E7, lipocalin-2 was identified as being upregulated in these cells by cDNA microarray analysis. Lipocalin-2 is known to be overexpressed in many human cancers and is implicated in the regulation of cell proliferation, differentiation and apoptosis. In this study, increased le...

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Publication status:
Published

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Publisher copy:
10.1099/vir.0.025064-0

Authors


Zigrino, P More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
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Journal:
The Journal of general virology
Volume:
92
Issue:
Pt 2
Pages:
395-401
Publication date:
2011-02-05
DOI:
EISSN:
1465-2099
ISSN:
0022-1317
URN:
uuid:3123e323-77f8-4fd8-aef9-f415f610bd06
Source identifiers:
175323
Local pid:
pubs:175323

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