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A soluble-phase proinsulin radioimmunoassay and its use in diagnosis of hypoglycaemia.

Abstract:

A soluble-phase proinsulin assay has been developed which does not require solid-phase antibody-binding. A human proinsulin standard curve is prepared in insulin-free and proinsulin-free plasma for comparison with unknown plasma samples. Proinsulin and insulin are bound with excess anti-insulin antiserum, and free C-peptide is removed by charcoal adsorption. The supernatant is then assayed using a routine C-peptide radioimmunoassay which utilises anti-C-peptide antiserum. The sensitivity of t...

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Publication status:
Published

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Publisher copy:
10.1177/000456328702400404

Authors


Journal:
Annals of clinical biochemistry
Volume:
24 ( Pt 4)
Issue:
4
Pages:
352-363
Publication date:
1987-07-05
DOI:
EISSN:
1758-1001
ISSN:
0004-5632
URN:
uuid:311c1db5-cb70-4100-94e1-68fa4a69983f
Source identifiers:
72747
Local pid:
pubs:72747

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