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Connecting the mechanisms of T-cell regulation: dendritic cells as the missing link.

Abstract:

A variety of different molecular mechanisms have been proposed to explain the suppressive action of regulatory T cells, including the production of anti-inflammatory cytokines, negative costimulatory ligands, indoleamine 2,3-dioxygenase-mediated tryptophan catabolism, CD73-mediated adenosine generation, and downregulation of antigen-presenting cells. Until now it has been unclear how important each of these different mechanisms might be and how they are coordinated. In this review, we examine...

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Publication status:
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Regateiro, FS More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Journal:
Immunological reviews
Volume:
236
Issue:
1
Pages:
203-218
Publication date:
2010-07-05
DOI:
EISSN:
1600-065X
ISSN:
0105-2896
URN:
uuid:311a0e95-086a-4f6c-aa98-cf07bde4adb1
Source identifiers:
60634
Local pid:
pubs:60634

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